dihomo-linolenoyl-choline to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174559

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.202
Position:
61581656
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
9.091
Reference Allele:
G
-log10(P):
-43.767
MAF:
0.274
Beta (Num):
0.088
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.114
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Phospholipid biosynthesis5[1], 6[2]

Ratio Explanation:

The ratio reflects the activity of FADS1, which desaturates fatty acids. A higher ratio may indicate lower FADS1 activity, leading to an accumulation of the precursor (dihomo-linolenoyl-choline) relative to other fatty acids.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by an altered dihomo-linolenoyl-choline to 1-stearoyl-gpc ratio, is associated with changes in lipid profiles and inflammatory responses, potentially increasing the risk for asthma and disorders of lipoprotein metabolism.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data