dihomo-linolenoyl-choline to docosahexaenoylcholine

Numerator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Denominator Metabolite

Structure of docosahexaenoylcholine
Metabolite Accession: GCST90200091
Name: docosahexaenoylcholine
Hmdb Id: HMDB0240647
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQLFEDZOXQQFGP

Associated Genomic Regions

Region: rs174538

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.128
Position:
61560081
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
10.116
Reference Allele:
G
-log10(P):
-53.721
MAF:
0.310
Beta (Num):
0.083
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.044
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 FEN1 FADS2 MYRF FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio reflects the balance between omega-6 (dihomo-linolenoyl-choline) and omega-3 (docosahexaenoylcholine) synthesis, which is governed by the activity of FADS enzymes.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the production of omega-6 and omega-3 polyunsaturated fatty acids, which are key mediators of inflammation and lipid levels.3[1], 4[2], 5[3] This dysregulation affects susceptibility to hypercholesterolemia, cholelithiasis, and inflammatory conditions like asthma and dermatitis.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data