dihomo-linolenoyl-choline to stearoylcholine*

Numerator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Denominator Metabolite

Structure of stearoylcholine*
Metabolite Accession: GCST90200113
Name: stearoylcholine*
Hmdb Id: HMDB0240648
Super Pathway: NA
Sub Pathway: NA
Inchikey: SGFBLYBOTWZDDE

Associated Genomic Regions

Region: rs174559

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.104
Position:
61581656
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
9.347
Reference Allele:
G
-log10(P):
-46.159
MAF:
0.274
Beta (Num):
0.088
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.016
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl cholines)4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl cholines)4[1], 5[2]

Ratio Explanation:

The ratio reflects the conversion of saturated to polyunsaturated fatty acids. FADS1 is implicated in this process and in regulating inflammatory lipids.6[1], 7[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 variants influence fatty acid metabolism, impacting inflammatory and lipid profiles, which are associated with disorders of lipoprotein metabolism, cholelithiasis, and inflammatory conditions like phlebitis and sinusitis.8[1], 7[2], 9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data