docosahexaenoylcholine to linoleoylcholine*

Numerator Metabolite

Structure of docosahexaenoylcholine
Metabolite Accession: GCST90200091
Name: docosahexaenoylcholine
Hmdb Id: HMDB0240647
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQLFEDZOXQQFGP

Denominator Metabolite

Structure of linoleoylcholine*
Metabolite Accession: GCST90200130
Name: linoleoylcholine*
Hmdb Id: HMDB0013213
Super Pathway: NA
Sub Pathway: NA
Inchikey: FDCFEKFQGUEBOI

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.121
Position:
61569830
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
-10.517
Reference Allele:
C
-log10(P):
-57.896
MAF:
0.337
Beta (Num):
-0.049
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.072
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid metabolism, Phospholipid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid metabolism, Phospholipid biosynthesis

Ratio Explanation:

This ratio reflects the balance between omega-3 (docosahexaenoylcholine) and omega-6 (linoleoylcholine) fatty acid pathways, which is regulated by the activity of FADS enzymes.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variations in FADS1/FADS2 alter enzyme activity, impacting the balance of omega-3 and omega-6 fatty acids and their inflammatory (e.g., prostaglandins) and anti-inflammatory derivatives.7[1], 5[2], 8[3] This imbalance affects inflammatory and metabolic conditions like asthma, IBD, and hypercholesterolemia.5[4], 4[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data