caffeic acid sulfate to xanthurenate

Numerator Metabolite

Structure of caffeic acid sulfate
Metabolite Accession: GCST90200093
Name: caffeic acid sulfate
Hmdb Id: HMDB0041708
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNVAIAITQIIEMQ

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs1185978

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.190
Position:
25835895
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
8.983
Reference Allele:
G
-log10(P):
-42.779
MAF:
0.465
Beta (Num):
0.087
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.103
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A3 SLC17A1 SLC17A4 SLC17A2 HIST1H2BA

LLM Analysis

Numerator Metabolite Explanation:

Phenylpropanoid biosynthesis, secondary metabolite sulfation.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Tryptophan metabolism, kynurenine pathway.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio may reflect altered transport of urate and other organic anions by SLC17A4, impacting tryptophan metabolism, though a direct link is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role in urate transport directly links it to serum uric acid levels, a measured phenotype.1[1], 2[2], 4[3] This transporter's broad substrate specificity could influence the levels of other organic anions like caffeic acid sulfate and xanthurenate, potentially affecting hematological and metabolic traits.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data