caffeic acid sulfate to n-acetylphenylalanine

Numerator Metabolite

Structure of caffeic acid sulfate
Metabolite Accession: GCST90200093
Name: caffeic acid sulfate
Hmdb Id: HMDB0041708
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNVAIAITQIIEMQ

Denominator Metabolite

Structure of n-acetylphenylalanine
Metabolite Accession: GCST90200677
Name: n-acetylphenylalanine
Hmdb Id: HMDB0000512
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBQJSKKFNMDLON

Associated Genomic Regions

Region: rs1165178

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.229
Position:
25827516
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
11.441
Reference Allele:
G
-log10(P):
-68.123
MAF:
0.464
Beta (Num):
0.087
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.142
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 SLC17A2 HIST1H2BA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Phenylpropanoid biosynthesis.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Phenylalanine metabolism.9[1], 10[2]

Ratio Explanation:

The ratio likely reflects altered transport activity by SLC17A4, potentially influencing the balance between the transport of dietary phenolic acids and amino acid derivatives.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely modifies urate transport, directly impacting serum uric acid levels.11[1], 12[2] This renal-related function could secondarily influence hematological parameters like MCHC, MCH, and hemoglobin, which are associated phenotypes, potentially through effects on erythropoiesis or red blood cell lifespan.13[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data