1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.480
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
22.955
Reference Allele:
T
-log10(P):
-266.828
MAF:
0.347
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.249
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, polyunsaturated fatty acid metabolism. 5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, arachidonic acid metabolism. 8[1], 9[2]

Ratio Explanation:

The ratio reflects FADS desaturase activity, comparing a phosphatidylcholine with precursor fatty acids (18:2/18:3) to a phosphatidylinositol containing a downstream product, arachidonic acid (20:4).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the efficiency of polyunsaturated fatty acid synthesis, including arachidonic acid, a key inflammatory mediator. 1[1], 10[2], 11[3]This dysregulation of lipid metabolism is linked to inflammatory and metabolic phenotypes like cholelithiasis, type 2 diabetes, and hypercholesterolemia. 12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data