1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)* to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.452
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
22.249
Reference Allele:
T
-log10(P):
-250.839
MAF:
0.347
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.221
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, PUFA metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Phospholipid biosynthesis, Saturated fatty acid synthesis.5[1], 6[2]

Ratio Explanation:

This ratio contrasts a phospholipid containing polyunsaturated fatty acids (18:2, 18:3) with one containing saturated fatty acids (16:0), reflecting FADS1/FADS2 desaturase activity.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 variants alter desaturase efficiency, modifying the PUFA/SFA balance reflected in the ratio.8[1] This change in fatty acid pools impacts systemic lipid metabolism, increasing the risk for hypercholesterolemia and cholelithiasis, which have significant MR or PheWAS associations.9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data