1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.331
Position:
61588305
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
19.037
Reference Allele:
A
-log10(P):
-184.382
MAF:
0.345
Beta (Num):
0.233
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity, where higher values suggest increased desaturation of fatty acids, impacting the balance between different phosphatidylcholine species.2[1], 3[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene activity alters the balance of polyunsaturated and saturated fatty acids, influencing inflammatory pathways and lipid profiles, which are linked to cardiovascular diseases, inflammatory bowel disease, and hypercholesterolemia.1[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data