1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.309
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
17.015
Reference Allele:
T
-log10(P):
-147.815
MAF:
0.347
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.078
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism.1[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase activity, comparing a polyunsaturated phosphatidylcholine, whose synthesis is FADS-dependent, to a saturated phosphatidylethanolamine, indicating fatty acid desaturation efficiency.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid metabolism, a key process in inflammation.10[1], 11[2], 12[3] This dysregulation likely underlies associated inflammatory phenotypes like asthma, inflammatory bowel disease, and various forms of dermatitis by affecting the balance of pro-inflammatory and anti-inflammatory lipid mediators.13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data