1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)* to 1-arachidonoyl-gpe (20:4n6)*
Numerator Metabolite
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID
Denominator Metabolite
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO
Associated Genomic Regions
Region: rs102275
Click a 'Plot' button in the tables to the right to view a locus plot here.
Clumped rQTL variant
Loading Ratio Plot...
Loading Numerator Plot...
Loading Denominator Plot...
SNP Summary
Chr:
11
Beta (Ratio):
0.604
Position:
61557803
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
27.372
Reference Allele:
T
-log10(P):
-378.144
MAF:
0.347
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.372
SE (Den):
0.016
No CNV overlap
rQTL cluster:
Reaction Distance:
NA
Missense Variants in LD (with rs102275)
eQTL Colocalization
pQTL Colocalization
| Exposure Protein | P(alpha) | P(IVW) | Coloc H4 | Coloc (SuSiE) | Plot |
|---|---|---|---|---|---|
| SMPD3 | 0.006 | 9.53e-30 | 0.991 | NA |
GTEx eQTL Colocalization
| Tissue | Exposure Gene | P(alpha) | P(IVW) | Coloc H4 | Coloc (SuSiE) | Plot |
|---|---|---|---|---|---|---|
| Heart Left Ventricle | NFATC3 | 1.10e-05 | 5.43e-21 | 0.985 | 0.969 | |
| Whole Blood | SLC7A6 | 1.54e-05 | 1.18e-13 | 0.290 | 1.000 | |
| Thyroid | PLA2G15 | 3.73e-05 | 1.89e-25 | 0.992 | 0.999 | |
| Esophagus Mucosa | PLA2G15 | 5.01e-05 | 1.89e-25 | 0.990 | 0.976 | |
| Small Intestine Terminal Ileum | NFATC3 | 5.20e-05 | NA | 0.942 | NA | |
| Esophagus Gastroesophageal Junction | PRMT7 | 6.32e-05 | 5.23e-14 | 6.04e-14 | 1.000 | |
| Artery Tibial | PRMT7 | 6.59e-05 | 1.18e-13 | 4.51e-14 | 1.000 | |
| Artery Tibial | PLA2G15 | 6.77e-05 | 1.89e-25 | 0.932 | 0.860 | |
| Esophagus Gastroesophageal Junction | NFATC3 | 1.14e-04 | 4.32e-15 | 0.005 | 1.000 | |
| Nerve Tibial | PLA2G15 | 1.31e-04 | 5.80e-30 | 0.997 | 0.994 | |
| Esophagus Muscularis | PLA2G15 | 1.36e-04 | 3.97e-23 | 0.989 | 0.978 | |
| Esophagus Muscularis | PRMT7 | 1.38e-04 | 1.37e-13 | 2.77e-14 | 1.000 | |
| Breast Mammary Tissue | PLA2G15 | 1.98e-04 | NA | 0.984 | 0.968 | |
| Brain Cortex | SMPD3 | 2.26e-04 | NA | 0.802 | NA | |
| Brain Nucleus Accumbens Basal Ganglia | NFATC3 | 2.47e-04 | NA | 0.944 | NA | |
| Colon Sigmoid | PRMT7 | 3.20e-04 | 1.37e-13 | 3.80e-14 | 1.000 | |
| Adrenal Gland | PLA2G15 | 3.28e-04 | NA | 0.991 | 0.987 | |
| Thyroid | SLC7A6 | 3.88e-04 | 1.23e-17 | 3.06e-10 | 1.000 | |
| Spleen | NFATC3 | 3.91e-04 | 6.32e-09 | 0.912 | 1.000 | |
| Heart Atrial Appendage | NFATC3 | 4.72e-04 | NA | 0.901 | NA | |
| Pituitary | NFATC3 | 4.76e-04 | 1.31e-11 | 0.705 | 0.997 | |
| Spleen | SMPD3 | 4.90e-04 | NA | 0.811 | NA | |
| Thyroid | PRMT7 | 5.29e-04 | 0.057 | 3.79e-14 | 1.000 | |
| Colon Sigmoid | NFATC3 | 5.70e-04 | 3.88e-15 | 2.62e-07 | 1.000 | |
| Nerve Tibial | NFATC3 | 6.00e-04 | 9.55e-10 | 2.10e-08 | 1.000 | |
| Colon Transverse | SLC7A6 | 6.15e-04 | 1.12e-14 | 0.897 | 1.000 | |
| Nerve Tibial | PRMT7 | 8.58e-04 | 7.58e-08 | 1.61e-14 | 1.000 | |
| Colon Transverse | NFATC3 | 8.75e-04 | 1.89e-25 | 0.961 | 1.000 | |
| Adipose Visceral Omentum | PLA2G15 | 9.65e-04 | NA | 0.992 | 0.986 | |
| Esophagus Mucosa | NFATC3 | 0.001 | 6.17e-10 | 0.840 | NA | |
| Brain Nucleus Accumbens Basal Ganglia | PRMT7 | 0.001 | 2.20e-13 | 2.61e-05 | 1.000 | |
| Adipose Subcutaneous | PLA2G15 | 0.001 | NA | 0.948 | NA | |
| Artery Coronary | PLA2G15 | 0.002 | NA | 0.890 | NA | |
| Thyroid | SLC7A6OS | 0.002 | NA | 0.886 | NA | |
| Esophagus Muscularis | NFATC3 | 0.002 | 9.55e-10 | 0.007 | 1.000 | |
| Artery Coronary | PRMT7 | 0.002 | 7.58e-08 | 3.39e-09 | 1.000 | |
| Whole Blood | NFATC3 | 0.003 | 5.43e-21 | 0.297 | 0.999 | |
| Brain Caudate Basal Ganglia | NFATC3 | 0.003 | NA | 0.835 | NA | |
| Heart Left Ventricle | PLA2G15 | 0.003 | NA | 0.872 | NA | |
| Pancreas | PRMT7 | 0.003 | 1.12e-14 | 5.19e-13 | 1.000 | |
| Nerve Tibial | SLC7A6 | 0.003 | 6.23e-11 | 0.950 | 0.996 | |
| Adipose Visceral Omentum | NFATC3 | 0.003 | 9.55e-10 | 0.314 | 0.993 | |
| Colon Transverse | PRMT7 | 0.003 | 1.37e-13 | 3.79e-14 | 1.000 | |
| Stomach | PRMT7 | 0.003 | 1.37e-13 | 6.77e-14 | 1.000 | |
| Skin Not Sun Exposed Suprapubic | PRMT7 | 0.003 | 5.23e-14 | 5.52e-14 | 1.000 | |
| Esophagus Mucosa | PRMT7 | 0.003 | 6.79e-13 | 2.02e-14 | 1.000 | |
| Adipose Subcutaneous | PRMT7 | 0.003 | 7.58e-08 | 1.89e-14 | 1.000 | |
| Lung | SLC7A6 | 0.003 | 3.88e-15 | 6.55e-04 | 1.000 | |
| Pancreas | NFATC3 | 0.004 | NA | 0.969 | 0.954 | |
| Breast Mammary Tissue | NFATC3 | 0.004 | 2.20e-13 | 0.927 | 0.998 | |
| Muscle Skeletal | SLC7A6 | 0.005 | NA | 0.976 | NA | |
| Spleen | PRMT7 | 0.005 | 1.37e-13 | 2.19e-11 | 1.000 | |
| Brain Cortex | PRMT7 | 0.006 | 7.58e-08 | 9.27e-08 | 1.000 | |
| Breast Mammary Tissue | PRMT7 | 0.006 | 5.23e-14 | 2.26e-11 | 1.000 | |
| Lung | NFATC3 | 0.006 | 1.31e-11 | 0.002 | 1.000 | |
| Heart Atrial Appendage | PLA2G15 | 0.007 | NA | 0.955 | NA | |
| Skin Sun Exposed Lower Leg | PRMT7 | 0.007 | 5.23e-14 | 9.53e-14 | 1.000 | |
| Lung | PRMT7 | 0.008 | 0.749 | 7.88e-17 | 1.000 | |
| Brain Cerebellum | NFATC3 | 0.008 | 5.43e-21 | 0.984 | 0.977 | |
| Skin Not Sun Exposed Suprapubic | NFATC3 | 0.008 | 6.17e-10 | 0.009 | 1.000 | |
| Liver | PRMT7 | 0.009 | 1.37e-13 | 1.77e-09 | 1.000 | |
| Skin Sun Exposed Lower Leg | PLA2G15 | 0.013 | 7.27e-12 | 5.24e-05 | 1.000 | |
| Thyroid | NFATC3 | 0.015 | 6.32e-09 | 4.81e-09 | 1.000 | |
| Adipose Visceral Omentum | PRMT7 | 0.015 | 1.37e-13 | 5.01e-14 | 1.000 | |
| Artery Aorta | PRMT7 | 0.016 | 7.58e-08 | 1.15e-17 | 1.000 | |
| Pituitary | PRMT7 | 0.018 | 1.12e-14 | 8.78e-07 | 1.000 | |
| Adipose Subcutaneous | NFATC3 | 0.019 | 9.55e-10 | 2.47e-05 | 1.000 | |
| Skin Sun Exposed Lower Leg | NFATC3 | 0.019 | 6.32e-09 | 0.990 | 0.172 | |
| Brain Caudate Basal Ganglia | PRMT7 | 0.031 | 2.31e-14 | 4.24e-06 | 1.000 | |
| Testis | PLA2G15 | 0.040 | 1.18e-13 | 0.004 | 0.998 | |
| Artery Tibial | NFATC3 | 0.044 | 0.359 | 1.01e-15 | 1.000 | |
| Whole Blood | PRMT7 | 0.045 | 0.670 | 1.27e-13 | 1.000 | |
| Small Intestine Terminal Ileum | PRMT7 | 0.051 | 1.37e-13 | 2.58e-07 | 1.000 | |
| Vagina | PRMT7 | 0.052 | 2.20e-13 | 0.015 | 1.000 | |
| Brain Cerebellum | PRMT7 | 0.057 | 0.262 | 1.13e-05 | 0.996 | |
| Prostate | PRMT7 | 0.058 | 5.23e-14 | 4.47e-09 | 1.000 | |
| Artery Aorta | NFATC3 | 0.070 | 0.308 | 6.89e-08 | 0.999 | |
| Muscle Skeletal | PRMT7 | 0.078 | 6.81e-15 | 2.20e-12 | 1.000 | |
| Brain Cerebellar Hemisphere | PRMT7 | 0.165 | 0.255 | 8.71e-06 | 0.998 | |
| Brain Frontal Cortex Ba9 | PRMT7 | 0.210 | 0.316 | 1.95e-04 | 0.999 | |
| Whole Blood | DUS2 | 0.327 | 0.316 | 9.89e-24 | 1.000 |
LLM Analysis
Numerator Metabolite Explanation:
Glycerophospholipid metabolism
Denominator Metabolite Explanation:
Glycerophospholipid metabolism
Ratio Explanation:
The ratio reflects the conversion of linoleic/linolenic acid to arachidonic acid, a key step in fatty acid metabolism regulated by FADS enzymes.
Ratio Evidence:
reaction where the ratio is shared through a pathway
Gene Ratio Phenotype Relationship:
Reduced FADS1/FADS2 activity, indicated by a higher ratio, alters fatty acid profiles. This dysregulation is linked to hypercholesterolemia and cholelithiasis, potentially through effects on inflammation and lipid metabolism.8[1], 9[2], 10[3], 11[4], 12[5], 13[6]
Phenotype Driver:
Gene-centric:FADS1/FADS2
Downloads
Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)
Download rQTL Data