1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.516
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
26.991
Reference Allele:
A
-log10(P):
-367.780
MAF:
0.351
Beta (Num):
0.270
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.246
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, omega-3 fatty acid metabolism.

Denominator Metabolite Explanation:

Phospholipid and Inositol phosphate metabolism.

Ratio Explanation:

The ratio reflects polyunsaturated fatty acid metabolism, comparing a phosphatidylcholine containing an omega-3 fatty acid to a phosphatidylinositol containing arachidonic acid, whose synthesis depends on FADS1/FADS2.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter PUFA synthesis, impacting the balance of pro- and anti-inflammatory lipid mediators.3[1], 4[2] This dysregulation of inflammation and lipid profiles contributes to the risk of associated phenotypes like cholelithiasis, type 2 diabetes, and hypercholesterolemia.5[3], 6[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data