1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.367
Position:
61588305
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
20.198
Reference Allele:
A
-log10(P):
-207.215
MAF:
0.351
Beta (Num):
0.270
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid Biosynthesis, Fatty Acid Metabolism

Denominator Metabolite Explanation:

Phospholipid Metabolism, Glycerophospholipid Metabolism

Ratio Explanation:

The ratio reflects FADS enzyme activity, comparing a polyunsaturated phosphatidylcholine (numerator) to a saturated lysophosphatidylcholine (denominator), indicating the balance between saturated and unsaturated fatty acid pools.2[1], 1[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster alter desaturase activity, impacting the balance of polyunsaturated fatty acids.3[1], 2[2] This dysregulation is associated with inflammatory (Asthma, IBD) and cardiometabolic (hypercholesterolemia, cholelithiasis) phenotypes due to changes in pro- and anti-inflammatory lipid mediator production.4[3], 5[4], 6[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data