1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-palmitoyl-gpc (16:0)

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.333
Position:
61592362
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
18.866
Reference Allele:
A
-log10(P):
-181.129
MAF:
0.352
Beta (Num):
0.269
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.063
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid degradation.

Ratio Explanation:

The ratio reflects FADS-mediated desaturation of fatty acids and their incorporation into phosphatidylcholines (numerator) versus the availability of lysophosphatidylcholine (denominator) for reacylation, indicating phospholipid turnover.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters enzyme activity, impacting PUFA levels.3[1] This change, reflected by the ratio, influences lipid profiles and inflammatory pathways, contributing to phenotypes like cholelithiasis, hypercholesterolemia, and inflammatory conditions such as dermatitis and asthma.4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data