1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.540
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
24.769
Reference Allele:
A
-log10(P):
-310.193
MAF:
0.351
Beta (Num):
0.270
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

PUFA biosynthesis, endocannabinoid signaling.1[1], 4[2], 5[3]

Ratio Explanation:

This ratio likely reflects FADS enzyme activity, contrasting a phosphatidylcholine with a precursor fatty acid (18:3) against a downstream monoacylglycerol product containing arachidonic acid (20:4).1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid (PUFA) synthesis, reflected in the ratio.7[1], 8[2], 6[3] This dysregulation of PUFAs, precursors to inflammatory molecules, likely contributes to inflammatory and metabolic phenotypes like asthma, inflammatory bowel disease, type 2 diabetes, and cholelithiasis.9[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data