1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.345
Position:
61592362
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
19.693
Reference Allele:
A
-log10(P):
-197.115
MAF:
0.352
Beta (Num):
0.269
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.075
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis.3[1]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.4[1]

Ratio Explanation:

This ratio may reflect FADS1/FADS2 desaturase activity, which alters the pool of fatty acids like linolenic acid available for incorporation into different phospholipids.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity impacts the balance of pro- and anti-inflammatory polyunsaturated fatty acids and their derivatives, contributing to inflammatory conditions like cholelithiasis and dermatitis.7[1], 1[2], 8[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data