1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-arachidonoyl-gpc (20:4n6)*

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-arachidonoyl-gpc (20:4n6)*
Metabolite Accession: GCST90199788
Name: 1-arachidonoyl-gpc (20:4n6)*
Hmdb Id: HMDB0010395
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAXQYRRMGGEGOH

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.828
Position:
61549025
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
37.708
Reference Allele:
G
-log10(P):
-714.808
MAF:
0.345
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.561
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase efficiency, where a higher value suggests lower conversion of fatty acid precursors to arachidonic acid, a key inflammatory mediator.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, affecting the balance of pro- and anti-inflammatory lipids. This dysregulation of fatty acid metabolism is linked to phenotypes like hypercholesterolemia, cholelithiasis, and asthma by influencing systemic inflammation and lipid profiles.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data