1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to 1-arachidonoyl-gpe (20:4n6)*

Numerator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Denominator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.640
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
31.203
Reference Allele:
A
-log10(P):
-490.482
MAF:
0.351
Beta (Num):
0.270
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.370
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid metabolism

Ratio Explanation:

The ratio reflects the activity of FADS1/FADS2 enzymes, where higher activity leads to increased arachidonic acid (denominator) and potentially altered levels of other fatty acids (numerator).3[1], 8[2], 10[3], 11[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster (FADS1/FADS2) alter enzyme activity, impacting the balance of pro-inflammatory and anti-inflammatory fatty acids.1[1], 2[2], 3[3], 4[4], 5[5], 8[6], 10[7] This dysregulation is associated with inflammatory conditions like IBD and skin disorders, and also with cholelithiasis and altered lipid profiles, potentially explaining the link to follicular cysts through disrupted fatty acid signaling.13[8], 14[9], 15[10], 16[11], 17[12]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data