linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.595
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
-26.099
Reference Allele:
A
-log10(P):
-344.063
MAF:
0.338
Beta (Num):
-0.316
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.278
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism, Diacylglycerol synthesis.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.4[1], 5[2]

Ratio Explanation:

This ratio may reflect the rate of desaturation of linoleic acid (18:2) to arachidonic acid (20:4) by FADS enzymes and its subsequent incorporation into diacylglycerols.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected by the lipid ratio, influences the availability of fatty acids for complex lipid synthesis. This dysregulation is linked to hypercholesterolemia, cholelithiasis, and inflammatory skin conditions like follicular cysts, supported by MR and PheWAS data.6[1], 7[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data