hexadecadienoate (16:2n6) to stearidonate (18:4n3)

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs1535

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.127
Position:
61597972
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
12.875
Reference Allele:
A
-log10(P):
-85.674
MAF:
0.343
Beta (Num):
0.009
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs6498540

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.080
Position:
15130594
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
7.798
Reference Allele:
A
-log10(P):
-32.699
MAF:
0.302
Beta (Num):
0.031
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.049
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism pathway4[1]

Denominator Metabolite Explanation:

Alpha-linolenic acid metabolism pathway5[1], 6[2]

Ratio Explanation:

This ratio reflects the balance between omega-6 and omega-3 fatty acid desaturation pathways, which are competitively regulated by FADS enzymes.7[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster alters desaturase activity, impacting the balance of pro-inflammatory (omega-6 derived) and anti-inflammatory (omega-3 derived) lipids, influencing metabolic and inflammatory phenotypes like cholelithiasis and type 2 diabetes.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data