hexadecadienoate (16:2n6) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.100
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-8.285
Reference Allele:
G
-log10(P):
-36.674
MAF:
0.176
Beta (Num):
-0.068
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, omega-6 metabolism.3[1]

Denominator Metabolite Explanation:

Omega-3/Omega-6 fatty acid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio of hexadecadienoate to linolenate may reflect the activity of desaturase enzymes like SCD, indicating an alteration in endogenous fatty acid synthesis.2[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, indicated by the fatty acid ratio, likely modulates lipid profiles.2[1], 7[2] This dyslipidemia contributes to the pathogenesis of associated cardiometabolic phenotypes, including atherosclerosis, hypercholesterolaemia, and myocardial infarction.2[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:[SCD]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data