hexadecadienoate (16:2n6) to stearate (18:0)

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.164
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-11.026
Reference Allele:
G
-log10(P):
-63.418
MAF:
0.176
Beta (Num):
-0.068
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, linoleic acid metabolism.3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects SCD enzyme activity, where lower levels indicate reduced conversion of stearate, a substrate, to downstream unsaturated fatty acids like hexadecadienoate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SCD activity, indicated by a higher stearate to hexadecadienoate ratio, is linked to altered lipid metabolism.1[1], 2[2] This alteration is associated with an increased risk of coronary atherosclerosis and hypercholesterolemia.1[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data