hexadecadienoate (16:2n6) to palmitate (16:0)

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.114
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-9.441
Reference Allele:
G
-log10(P):
-47.046
MAF:
0.176
Beta (Num):
-0.068
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid desaturation and elongation.3[1], 4[2]

Denominator Metabolite Explanation:

De novo lipogenesis, Fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio of hexadecadienoate (16:2n6) to palmitate (16:0) reflects fatty acid desaturation activity, where SCD converts palmitate into monounsaturated fats.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD gene variants likely alter desaturase activity, modifying the hexadecadienoate to palmitate ratio. This altered fatty acid profile is associated with dyslipidemia and atherosclerosis, increasing the risk for cardiovascular phenotypes like myocardial infarction and hypertension.2[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data