4-hydroxyphenylacetylglutamine to indoleacetate

Numerator Metabolite

Structure of 4-hydroxyphenylacetylglutamine
Metabolite Accession: GCST90200106
Name: 4-hydroxyphenylacetylglutamine
Hmdb Id: HMDB0006061
Super Pathway: NA
Sub Pathway: NA
Inchikey: CYRKYXZJUIBBJX

Denominator Metabolite

Structure of indoleacetate
Metabolite Accession: GCST90199683
Name: indoleacetate
Hmdb Id: HMDB0000197
Super Pathway: NA
Sub Pathway: NA
Inchikey: SEOVTRFCIGRIMH

Associated Genomic Regions

Region: rs57674198

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.162
Position:
151876073
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
7.821
Reference Allele:
T
-log10(P):
-32.884
MAF:
0.292
Beta (Num):
0.088
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.074
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Tyrosine metabolism, Gut microbiome metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Tryptophan metabolism, Gut microbiome metabolism6[1], 7[2]

Ratio Explanation:

The ratio reflects competing gut microbial metabolic pathways from amino acids. THEM4's role in host metabolism may influence gut microbial composition or function.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Diverticular disease is associated with altered gut microbiota and connective tissue.8[1], 9[2], 10[3] THEM4 expression is linked to diverticular disease and influences mitochondrial function and apoptosis, potentially impacting gut wall integrity and the local inflammatory environment.11[4], 3[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data