linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]* to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.560
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-25.402
Reference Allele:
A
-log10(P):
-326.097
MAF:
0.338
Beta (Num):
-0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.233
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism, Polyunsaturated fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Polyunsaturated fatty acid biosynthesis.

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, comparing arachidonic acid (20:4) incorporation into diacylglycerol (numerator) with linolenic acid (18:3) incorporation into phosphatidylcholine (denominator).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase efficiency, impacting omega-6 (arachidonic acid) and omega-3 fatty acid balance.5[1], 6[2] This affects lipid profiles, contributing to hypercholesterolemia and cholelithiasis, which is supported by Mendelian randomization and PheWAS data showing associations with lipid traits.3[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data