palmitoleoylcarnitine (c16:1)* to laurylcarnitine

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.166
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-12.707
Reference Allele:
G
-log10(P):
-83.510
MAF:
0.176
Beta (Num):
-0.130
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.036
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs17843966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.101
Position:
159629814
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
8.896
Reference Allele:
A
-log10(P):
-41.989
MAF:
0.264
Beta (Num):
0.009
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.092
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
ETFDH PPID C4orf46 RXFP1 FNIP2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 6[2]

Ratio Explanation:

This ratio of a monounsaturated (C16:1) to a medium-chain saturated (C12) acylcarnitine likely reflects Stearoyl-CoA Desaturase (SCD) activity.1[1], 2[2], 7[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Increased SCD activity, reflected by the ratio, is associated with dyslipidemia and atherogenesis.2[1], 8[2] It alters lipid profiles and membrane composition, contributing to coronary artery disease risk as seen in the colocalized FinnGen traits.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data