palmitoleoylcarnitine (c16:1)* to 3-hydroxydodecanedioate*

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of 3-hydroxydodecanedioate*
Metabolite Accession: GCST90199769
Name: 3-hydroxydodecanedioate*
Hmdb Id: HMDB0000413
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYVQCLGZFXHEGL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.132
Position:
151879761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
7.781
Reference Allele:
G
-log10(P):
-32.564
MAF:
0.318
Beta (Num):
0.060
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.072
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.6[1]

Ratio Explanation:

The ratio likely reflects THEM4-modulated flux between mitochondrial long-chain fatty acid beta-oxidation (numerator) and alternative fatty acid oxidation pathways (denominator).1[1], 2[2], 6[3], 4[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered THEM4 expression, colocalized with diverticular disease, likely modifies fatty acid metabolism, evidenced by the ratio. This metabolic dysregulation could influence intestinal inflammation, a known factor in diverticular disease pathophysiology.1[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data