palmitoleoylcarnitine (c16:1)* to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12210538

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.141
Position:
110760008
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
14.199
Reference Allele:
A
-log10(P):
-103.686
MAF:
0.239
Beta (Num):
-0.066
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.206
SE (Den):
0.017
No CNV overlap
rQTL cluster:
103
Reaction Distance:
NA
Closest Genes:
SLC22A16 DDO METTL24 CDK19 CDC40

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

This ratio reflects the relative transport efficiency of two long-chain acylcarnitines by the SLC22A16 transporter, indicating alterations in fatty acid metabolism or transport.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A16 function modifies the palmitoleoylcarnitine to oleoylcarnitine ratio, indicating disrupted fatty acid metabolism, which is associated with changes in glycemic control (HbA1c) and red blood cell indices like MCV and bilirubin, potentially through lipotoxicity or altered cell membrane composition.8[1], 9[2], 10[3]

Phenotype Driver:

Metabolite-centric[palmitoleoylcarnitine (c16:1) and oleoylcarnitine (c18:1)]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data