palmitoleoylcarnitine (c16:1)* to myristate (14:0)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.182
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-10.194
Reference Allele:
G
-log10(P):
-54.513
MAF:
0.176
Beta (Num):
-0.130
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.052
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport, beta-oxidation5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis7[1]

Ratio Explanation:

The ratio of palmitoleoylcarnitine to myristate may reflect the balance between fatty acid transport/oxidation and fatty acid synthesis, influenced by carnitine availability.1[1], 7[2], 5[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine uptake, leading to altered fatty acid metabolism.2[1], 3[2] This dysregulation is associated with an increased risk of cardiovascular diseases, including myocardial infarction and ischemic heart disease, which are listed as associated phenotypes.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data