palmitoleoylcarnitine (c16:1)* to nonadecanoate (19:0)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.178
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-8.912
Reference Allele:
G
-log10(P):
-42.138
MAF:
0.176
Beta (Num):
-0.130
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.048
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation10[1], 11[2], 12[3]

Denominator Metabolite Explanation:

Fatty acid metabolism13[1], 14[2], 15[3], 16[4]

Ratio Explanation:

The ratio reflects the balance between endogenous synthesis of monounsaturated fatty acids (palmitoleoylcarnitine's precursor) and the levels of an exogenous, odd-chain saturated fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD-mediated synthesis of palmitoleic acid (the precursor to palmitoleoylcarnitine) is linked to hyperlipidemia. Altered levels of both metabolites are associated with cardiovascular and metabolic phenotypes, suggesting a complex interplay between endogenous fatty acid metabolism and exogenous fatty acid levels in these conditions.1[1], 2[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data