palmitoleoylcarnitine (c16:1)* to pentadecanoate (15:0)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.173
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-9.225
Reference Allele:
G
-log10(P):
-45.010
MAF:
0.176
Beta (Num):
-0.130
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.042
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects carnitine-dependent transport of monounsaturated fatty acids (C16:1) relative to the pool of odd-chain saturated fatty acids (C15:0).5[1], 8[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variation in the SLC22A5 carnitine transporter likely alters fatty acid oxidation.1[1], 5[2] This metabolic shift, indicated by the ratio, contributes to dyslipidemia and increased risk for cardiovascular phenotypes like myocardial infarction and ischemic heart disease.3[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data