sphingomyelin (d18:2/24:2)* to glycosyl ceramide (d18:2/24:1, d18:1/24:2)*

Numerator Metabolite

Structure of sphingomyelin (d18:2/24:2)*
Metabolite Accession: GCST90200124
Name: sphingomyelin (d18:2/24:2)*
Hmdb Id: HMDB0240644
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAWJSGKLPKMOGG

Denominator Metabolite

Metabolite Accession: GCST90200118
Name: glycosyl ceramide (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs35818294

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.292
Position:
47545141
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-18.332
Reference Allele:
C
-log10(P):
-171.165
MAF:
0.176
Beta (Num):
0.019
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.311
SE (Den):
0.019
No CNV overlap
rQTL cluster:
126
Reaction Distance:
NA
Closest Genes:
ATP10D CORIN COMMD8 GABRB1 NFXL1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid biosynthesis; ceramide metabolism.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Glycosphingolipid metabolism; ceramide metabolism.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

ATP10D-mediated transport of glycosyl ceramide from the outer to inner plasma membrane leaflet influences its availability for metabolism, potentially altering the balance with sphingomyelin.13[1], 14[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data