sphingomyelin (d18:2/21:0, d16:2/23:0)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Metabolite Accession: GCST90200129
Name: sphingomyelin (d18:2/21:0, d16:2/23:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.211
Position:
61569830
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-10.558
Reference Allele:
C
-log10(P):
-58.327
MAF:
0.339
Beta (Num):
-0.082
Novel Locus:
No
SE (Num):
0.013
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.5[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1]

Ratio Explanation:

The ratio reflects the balance between sphingolipid and glycerophospholipid pathways, modulated by FADS activity which influences the synthesis of fatty acid components of both lipids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid metabolism, influencing the balance of pro- and anti-inflammatory molecules, which contributes to risk for inflammatory bowel disease, valvular heart disease, and dyslipidemia.3[1], 7[2], 8[3], 9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data