linoleoylcholine* to glycerophosphorylcholine (gpc)

Numerator Metabolite

Structure of linoleoylcholine*
Metabolite Accession: GCST90200130
Name: linoleoylcholine*
Hmdb Id: HMDB0013213
Super Pathway: NA
Sub Pathway: NA
Inchikey: FDCFEKFQGUEBOI

Denominator Metabolite

Structure of glycerophosphorylcholine (gpc)
Metabolite Accession: GCST90199629
Name: glycerophosphorylcholine (gpc)
Hmdb Id: HMDB0000086
Super Pathway: NA
Sub Pathway: NA
Inchikey: SUHOQUVVVLNYQR

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.129
Position:
61557803
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
8.213
Reference Allele:
T
-log10(P):
-36.070
MAF:
0.346
Beta (Num):
0.069
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.060
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Phosphatidylcholine breakdown.11[1], 12[2], 13[3]

Ratio Explanation:

The ratio reflects the balance between fatty acid metabolism and phosphatidylcholine degradation. FADS enzymes influence the linoleoyl component, impacting overall lipid composition and related disease risks.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters polyunsaturated fatty acid metabolism, influencing the availability of linoleoylcholine. This dysregulation of lipid metabolism is linked to an increased risk of cholelithiasis and other metabolic disorders like Type 2 diabetes and hypercholesterolemia.14[1], 15[2], 16[3], 17[4], 18[5], 19[6], 20[7], 21[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data