linoleoylcholine* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of linoleoylcholine*
Metabolite Accession: GCST90200130
Name: linoleoylcholine*
Hmdb Id: HMDB0013213
Super Pathway: NA
Sub Pathway: NA
Inchikey: FDCFEKFQGUEBOI

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.178
Position:
61581764
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
9.035
Reference Allele:
T
-log10(P):
-43.254
MAF:
0.308
Beta (Num):
0.062
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Acyl-choline metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid pathway.7[1], 8[2]

Ratio Explanation:

The ratio of linoleoylcholine (containing an omega-6 fatty acid) to 1-stearoyl-gpc (containing a saturated fatty acid) reflects FADS desaturase activity on fatty acid pools.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, which is a key factor in cholesterol regulation and inflammatory processes.9[1], 10[2] This is linked to phenotypes like cholelithiasis and hypercholesterolemia, as bile composition and lipoprotein metabolism are directly affected.11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data