linoleoylcholine* to stearoylcholine*

Numerator Metabolite

Structure of linoleoylcholine*
Metabolite Accession: GCST90200130
Name: linoleoylcholine*
Hmdb Id: HMDB0013213
Super Pathway: NA
Sub Pathway: NA
Inchikey: FDCFEKFQGUEBOI

Denominator Metabolite

Structure of stearoylcholine*
Metabolite Accession: GCST90200113
Name: stearoylcholine*
Hmdb Id: HMDB0240648
Super Pathway: NA
Sub Pathway: NA
Inchikey: SGFBLYBOTWZDDE

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.090
Position:
61592362
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
8.046
Reference Allele:
A
-log10(P):
-34.696
MAF:
0.345
Beta (Num):
0.069
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.020
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.8[1], 7[2], 9[3]

Ratio Explanation:

The ratio of linoleoylcholine (polyunsaturated) to stearoylcholine (saturated) reflects the activity of fatty acid desaturase enzymes encoded by the FADS gene cluster.10[1], 11[2], 12[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting the balance of fatty acids which influences plasma lipids and inflammatory processes.1[1], 13[2] This links to metabolic phenotypes (hypercholesterolemia, cholelithiasis, Type 2 diabetes) and inflammatory conditions (asthma, sinusitis) through effects on cell membranes and signaling molecules.3[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data