arachidoylcarnitine (c20)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of arachidoylcarnitine (c20)*
Metabolite Accession: GCST90200135
Name: arachidoylcarnitine (c20)*
Hmdb Id: HMDB0006460
Super Pathway: NA
Sub Pathway: NA
Inchikey: SVJLJQBGUITFLI

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.196
Position:
61579463
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-10.758
Reference Allele:
A
-log10(P):
-60.477
MAF:
0.337
Beta (Num):
-0.069
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the balance between very-long-chain saturated fatty acid metabolism (C20) and linoleic acid-containing lysophospholipid (LysoPC 18:2) availability, influenced by FADS desaturase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis.2[1], 3[2] This dysregulation, reflected by the lipid ratio, influences inflammatory responses and lipid profiles, contributing to phenotypes like inflammatory bowel disease, cholelithiasis, and disorders of lipoprotein metabolism.4[3], 5[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data