lignoceroylcarnitine (c24)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of lignoceroylcarnitine (c24)*
Metabolite Accession: GCST90200137
Name: lignoceroylcarnitine (c24)*
Hmdb Id: HMDB0240665
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDUFZFUYBBPVLJ

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.185
Position:
61579463
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-9.837
Reference Allele:
A
-log10(P):
-50.903
MAF:
0.337
Beta (Num):
-0.058
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Peroxisomal beta-oxidation, Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio compares very-long-chain saturated fatty acid metabolism (lignoceroylcarnitine) with polyunsaturated fatty acid metabolism (linoleoyl-gpc), potentially reflecting FADS enzyme activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter polyunsaturated fatty acid levels, impacting lipid and inflammatory pathways.2[1], 4[2] This dysregulation plausibly contributes to associated metabolic (Type 2 diabetes, hypercholesterolemia) and inflammatory (asthma, phlebitis, cholelithiasis) phenotypes.10[3], 11[4], 12[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data