docosatrienoate (22:3n6)* to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.206
Position:
61588305
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-11.210
Reference Allele:
A
-log10(P):
-65.478
MAF:
0.285
Beta (Num):
-0.190
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.8[1]

Ratio Explanation:

The ratio reflects the activity of FADS1 and FADS2 enzymes, which are involved in the synthesis of the numerator but not the denominator.9[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster influence enzyme activity, altering fatty acid profiles.4[1], 5[2], 10[3] This dysregulation is associated with an increased risk for inflammatory conditions like cholelithiasis, type 2 diabetes, and inflammatory bowel disease.11[4], 12[5], 13[6], 14[7], 15[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data