docosatrienoate (22:3n6)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.319
Position:
61569830
SE (Ratio):
0.028
Effect Allele:
T
Z-score (Ratio):
-11.309
Reference Allele:
C
-log10(P):
-66.602
MAF:
0.281
Beta (Num):
-0.190
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.8[1], 9[2], 12[3]

Denominator Metabolite Explanation:

Phospholipid metabolism, fatty acid metabolism.1[1], 11[2], 13[3]

Ratio Explanation:

This ratio reflects the enzymatic efficiency of FADS1/FADS2 in converting linoleic acid (a component of the denominator) into downstream products, including precursors of docosatrienoate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, is associated with altered lipid profiles (hypercholesterolemia, dyslipidemia) and inflammatory conditions, increasing the risk for cholelithiasis and type 2 diabetes.14[1], 15[2], 16[3], 17[4], 18[5], 19[6], 20[7], 21[8], 22[9], 23[10]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data