docosatrienoate (22:3n6)* to eicosenoate (20:1)

Numerator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.208
Position:
61551927
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-10.994
Reference Allele:
A
-log10(P):
-63.067
MAF:
0.283
Beta (Num):
-0.192
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.016
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid elongation/biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS1 (delta-5 desaturase) activity, which is involved in converting fatty acid precursors into longer-chain polyunsaturated fatty acids like docosatrienoate.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity is linked to altered fatty acid profiles and lipid metabolism, which are associated with cholelithiasis, hypercholesterolemia, and benign colon neoplasms.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data