docosatrienoate (22:3n6)* to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.348
Position:
61571348
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
-13.882
Reference Allele:
C
-log10(P):
-99.212
MAF:
0.253
Beta (Num):
-0.195
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.152
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Omega-3/Omega-6 fatty acid biosynthesis, fatty acid oxidation.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of docosatrienoate to dihomo-linolenoylcarnitine reflects the activity of FADS-mediated desaturation and elongation in the polyunsaturated fatty acid (PUFA) synthesis pathway.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters PUFA metabolism, impacting the balance of inflammatory lipids.9[1], 10[2] This dysregulation is linked to inflammatory and metabolic phenotypes like cholelithiasis, hypercholesterolemia, and asthma, which are consistent with the associated FinnGen and BioBank Japan traits.11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data