docosatrienoate (22:3n6)* to palmitoleate (16:1n7)

Numerator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.204
Position:
61571348
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-10.718
Reference Allele:
C
-log10(P):
-60.046
MAF:
0.253
Beta (Num):
-0.195
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.2[1], 7[2]

Denominator Metabolite Explanation:

De novo lipogenesis, omega-7 fatty acid biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio of docosatrienoate (n-6) to palmitoleate (n-7) reflects FADS-mediated polyunsaturated fatty acid synthesis relative to monounsaturated fatty acid synthesis from palmitic acid.1[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, impacting the balance of various fatty acids.11[1], 12[2], 13[3], 14[4] This dysregulation of lipid metabolism and inflammatory precursors contributes to the observed phenotypes, including hypercholesterolemia, cholelithiasis, and asthma.15[5], 16[6], 14[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data