dihomo-linolenoylcarnitine (c20:3n3 or 6)* to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.379
Position:
61581764
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
16.637
Reference Allele:
T
-log10(P):
-141.431
MAF:
0.308
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of FADS1 in converting upstream precursors to downstream products, balanced against glycerophospholipid synthesis, influencing inflammatory and metabolic pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence its enzymatic activity, altering the production of pro-inflammatory and pro-resolving lipid mediators derived from polyunsaturated fatty acids.7[1], 8[2], 9[3], 10[4], 11[5], 12[6], 13[7], 14[8] This dysregulation is linked to inflammatory skin conditions like seborrhoeic and infective dermatitis, and potentially asthma, through its impact on immune responses.7[9], 11[10], 15[11], 12[12], 16[13], 13[14], 17[15], 18[16]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data