dihomo-linolenoylcarnitine (c20:3n3 or 6)* to palmitoylcarnitine (c16)

Numerator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs61897793

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.304
Position:
61599347
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
15.574
Reference Allele:
G
-log10(P):
-124.246
MAF:
0.180
Beta (Num):
0.239
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.065
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

Region: rs2229738

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.296
Position:
68562328
SE (Ratio):
0.029
Effect Allele:
T
Z-score (Ratio):
10.102
Reference Allele:
C
-log10(P):
-53.574
MAF:
0.071
Beta (Num):
0.217
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
-0.078
SE (Den):
0.030
No CNV overlap
rQTL cluster:
57
Reaction Distance:
NA
Closest Genes:
CPT1A MTL5 MRPL21 GAL IGHMBP2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Denominator Metabolite Explanation:

Fatty acid oxidation/metabolism8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the balance between fatty acid synthesis/desaturation (dihomo-linolenoylcarnitine) and fatty acid oxidation (palmitoylcarnitine), influenced by FADS and CPT1A enzyme activities.4[1], 11[2], 2[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS activity, influenced by genetic factors, can shift the balance of pro-inflammatory and anti-inflammatory lipid mediators, contributing to inflammatory conditions like asthma and dermatitis.4[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data