dihomo-linolenoylcarnitine (c20:3n3 or 6)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.408
Position:
61596633
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
19.300
Reference Allele:
C
-log10(P):
-189.426
MAF:
0.345
Beta (Num):
0.141
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.268
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Endocannabinoid signaling6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the activity of FADS1, which synthesizes the precursor for 1-arachidonylglycerol (20:4) from fatty acids like dihomo-gamma-linolenic acid (a precursor to C20:3n6).1[1], 9[2], 3[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by a higher ratio, is linked to altered lipid profiles, including lower HDL and higher triglycerides, and an increased risk for cholelithiasis, type 2 diabetes, and asthma.10[1], 11[2], 12[3], 13[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data