dihomo-linolenoylcarnitine (c20:3n3 or 6)* to 1-arachidonoyl-gpe (20:4n6)*

Numerator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.540
Position:
61581764
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
27.984
Reference Allele:
T
-log10(P):
-395.125
MAF:
0.308
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.385
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Carnitine synthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Linoleic acid metabolism, Glycerophospholipid metabolism.6[1]

Ratio Explanation:

The ratio of dihomo-linolenoylcarnitine to 1-arachidonoyl-gpe reflects the efficiency of FADS1 in converting dihomo-gamma-linolenic acid (DGLA) to arachidonic acid (AA).7[1], 2[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter its desaturase activity, impacting the balance of pro-inflammatory (from AA) and anti-inflammatory (from DGLA) lipids.9[1], 7[2] This dysregulation affects lipid metabolism and inflammatory responses, contributing to phenotypes like asthma, dermatitis, and hypercholesterolaemia.1[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data