dihomo-linolenoylcarnitine (c20:3n3 or 6)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*

Numerator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs28456

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.483
Position:
61589481
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
21.304
Reference Allele:
A
-log10(P):
-230.226
MAF:
0.309
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.328
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Fatty acid metabolism

Denominator Metabolite Explanation:

Glycerolipid metabolism, Endocannabinoid synthesis

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase efficiency, where lower genetic activity decreases the conversion of dihomo-linolenic acid to arachidonic acid, affecting the balance of these glycerolipids.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, influenced by genetic factors, alters the balance of pro-inflammatory and pro-resolving lipid mediators, contributing to inflammatory skin conditions like seborrhoeic dermatitis and atopic eczema, and potentially asthma, by affecting skin barrier function and immune responses.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data