dihomo-linolenoylcarnitine (c20:3n3 or 6)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*

Numerator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs28456

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.485
Position:
61589481
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
21.098
Reference Allele:
A
-log10(P):
-225.842
MAF:
0.309
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.330
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerolipid metabolism, fatty acid metabolism.5[1]

Ratio Explanation:

The ratio reflects FADS1 activity; higher values suggest reduced conversion of dihomo-linolenoylcarnitine's fatty acid (DGLA) to the denominator's arachidonic acid component.1[1], 2[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters its desaturase activity, impacting the balance of inflammatory fatty acids.7[1], 1[2] This metabolic shift, reflected by the ratio, likely contributes to inflammatory skin conditions like seborrhoeic and infective dermatitis by modulating inflammatory mediators.8[3], 9[4]

Phenotype Driver:

Gene-centric:[FADS1]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data