dihomo-linoleoylcarnitine (c20:2)* to oleoylcarnitine (c18:1)

Numerator Metabolite

Metabolite Accession: GCST90200144
Name: dihomo-linoleoylcarnitine (c20:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102274

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.099
Position:
61557826
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
8.042
Reference Allele:
T
-log10(P):
-34.662
MAF:
0.341
Beta (Num):
0.040
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.059
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/biosynthesis5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism/transport8[1], 9[2]

Ratio Explanation:

An elevated ratio of dihomo-linoleoylcarnitine to oleoylcarnitine suggests altered FADS2 activity, impacting the balance of long-chain polyunsaturated fatty acid synthesis.10[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster are associated with altered FADS2 activity, which modifies the balance of fatty acids.1[1], 11[2] This altered lipid profile is linked to cholelithiasis, dyslipidemia, and inflammatory conditions, likely by influencing the synthesis of proinflammatory and proresolving lipid mediators.12[3], 13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data